ISIS has claimed responsibility for attacks in the Syrian cities of Damascus and Homs that claimed at least 140 lives, the BBC reports.
Four blasts in Syria's capital city killed at least 80 people on Sunday, while a double car bombing claimed 57 lives in the western city of Homs, according to state media and monitoring groups.
Syrian state television reported that over 200 people were injured in this latest wave of attacks in the war-torn country, according to Sky News.
The attacks appeared to target areas heavily populated by minorities.
Syria's holiest Shia Muslim shrine in Sayydia Zeinab was hit in the Damascus attacks, while in Homs, blasts affected a predominantly Alawite district.
Only last month, the Sayydia Zeinab district was hit by suicide attacks that left over 70 people dead, which ISIS (also known as the Islamic State, ISIL or Daesh) fighters claimed to have carried out.
The attack in Homs was one of the biggest blasts in the city since the civil war broke out five years ago, according to the Syrian Observatory for Human Rights.
Situated 100 miles north of Damascus, Homs was once perceived as the capital of the revolution but is now controlled by pro-government forces.
The attacks came just hours after at least 50 IS fighters were killed by a government advance on the city of Aleppo over the weekend.
Meanwhile, US Secretary of State John Kerry claims that negotiators have arrived at a "provisional agreement in principle" on a Syrian ceasefire.
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